England won on Monday the second Test against Pakistan in Multan, killing the hosts' hope to win the three-match Test series.
The visitors took an unassailable 2-0 lead in the three-match series, as Pakistan were all out for 328, while chasing 355 for victory in the second session on day four of the contest.
Saud Shakeel topscored for Pakistan with a valiant 94, while Imam-ul-Haq made 60.
Mark Wood was pick of the England bowlers, claiming 4-65 as England registered their first series win in Pakistan since 2000-01.
England will conclude their first test tour of Pakistan since 2005 with the third and final match beginning in Karachi on Saturday.
Earlier, when the day started Faheem Ashraf got out after scoring 10 runs. Later, Mohammad Nawaz and Saud Shakeel played responsibly and took the team closer to target before losing their wickets.
Saud Shakeel was the last man out just before lunch. He scored 94 runs and was given out in a decision called controversial by several former cricketers including ex-Pakaistan skipper Waqar Younus.
Set a challenging 355 runs for victory, Pakistan ended the third day at 198-4, needing another 157 with two full days remaining.
With reverse swing helping the fast bowlers, England derailed Pakistan’s start of 66 without loss with three wickets for just 17 runs.
But Haq (60) and Shakeel (54 not out) led a remarkable 156-minute fightback during their stand of 108 for the fourth wicket before Jack Leach had the former caught at slip three overs before stumps.
Haq, who came in at number five instead of opening the innings following hamstring treatment, hit seven boundaries.
Allrounder Faheem Ashraf, promoted to number six, was three not out as Pakistan chased a series-levelling win after losing the first of three Tests by 74 runs in Rawalpindi.
Earlier, spinner Abrar Ahmed took 11 wickets for 234 across the two innings -- the second best by a bowler on debut for Pakistan, behind Mohammad Zahid’s 11-130 against New Zealand in Rawalpindi 26 years ago.
Pakistan suffer seven-wicket defeat in final T20I
Refutes media report claiming Gillespie to be replaced by selection committee's convenor Aqib Javed
After the fight, Jones celebrates with US President-elect Donald Trump, shakes hands
PCB likely to appoint Javed ahead of upcoming series against Zimbabwe, say sources
Usmani defeats Turkmenistan's Suleyman Hudayberdiyev in final straight sets, conceding just one game
Starting today, tour will build excitement ahead of much-anticipated Champion's Trophy, set to take place in coming year